Microneedling with PDRN
Microneedling, with a biological repair signal your skin already understands.
Standard microneedling tells your skin to rebuild. Microneedling with PDRN gives it a more specific instruction — and a more targeted result.
PDRN is a purified DNA fragment, most commonly derived from salmon DNA, that promotes tissue repair by stimulating specific cellular pathways involved in healing and collagen production. Where standard microneedling relies on the skin's general healing response, PDRN directs that response with greater precision — activating the repair mechanisms that lead to real, measurable improvement in skin quality, texture, and resilience.
The result is the same foundation as standard microneedling — collagen, texture, tone — but with an enhanced and more targeted repair signal driving the process. For clients who want to get more from every session, or whose skin needs genuine regeneration alongside renewal, this is the considered upgrade.
What it Treats:
PDRN — Polydeoxyribonucleotide — is a purified DNA fragment derived from salmon DNA. It works differently from other microneedling adjuvants by stimulating specific cellular receptors involved in tissue repair and regeneration, activating the body's own healing pathways to produce collagen more efficiently and restore skin health at a cellular level.
Applied to the skin immediately after microneedling, when the microchannels created by treatment allow for maximum absorption, PDRN penetrates the deeper layers of the dermis where it can do its most meaningful work.
Most effective for:
Skin repair and regeneration · Fine lines and early laxity · Uneven tone and texture · Post-acne scarring · Skin sensitivity and compromised barrier function · Recovery from environmental damage · Clients seeking enhanced results beyond standard microneedling
What to Expect:
The treatment begins identically to standard microneedling — numbing, device pass, controlled microchannels created by the DP4 device. Immediately following, the PDRN solution is applied to the skin and absorbed through the open channels into the dermis.
Recovery is comparable to standard microneedling — redness and sensitivity for 24 to 48 hours, with most clients returning to normal activities the following day. The aftercare protocol is identical — gentle skincare, mineral SPF, no active ingredients for the first 48 to 72 hours.
Results:
When: Progressive improvement over 4 to 6 weeks per session as the cellular repair response builds
How long: Long-lasting with a series and periodic maintenance
What affects it: Skin condition, number of sessions, and aftercare compliance
IS THIS RIGHT FOR YOU?
Microneedling with PDRN is well-suited to clients focused on genuine skin repair and regeneration — those addressing scarring, sensitivity, barrier dysfunction, or skin that has been through environmental stress and needs more than routine stimulation. It suits all skin tones and most adults without contraindications to microneedling.
The Questions People Actually Ask:
01. What exactly is PDRN and where does it come from?
PDRN is Polydeoxyribonucleotide — a purified DNA fragment most commonly derived from salmon DNA. It works by stimulating specific cellular receptors involved in tissue repair and healing, activating the body's own collagen production pathways. It is not an exosome and does not work the same way — rather than sending signalling messages to cells, it directly stimulates the repair mechanisms involved in regeneration and healing.
02. How is this different from standard microneedling?
Standard microneedling relies on the skin's general healing response to drive collagen production. PDRN activates specific repair pathways that make that response more targeted and efficient — particularly for clients dealing with damaged skin, scarring, or compromised skin health. For clients with straightforward maintenance goals and healthy skin, standard microneedling delivers excellent results. PDRN is the more considered choice when repair is part of the goal.
03. How many sessions do I need?
Three sessions spaced four weeks apart is the standard starting protocol, with results building meaningfully across the series. Maintenance frequency depends on your skin and goals — Emily will advise based on how your skin responds.
